
The South African Football Association saying that Santana would step down his role with "immediate effect" and added it had been "unanimously agreed."
Santana took the reins in April 2008, replacing fellow Brazilian Carlos Alberto Parreira, who stepped down for personal reasons.
His first match saw a disappointing 2-0 away defeat to Nigeria before he steadied the ship with five straight wins against lowly African opposition.
A fourth-place finish in the Confederations Cup on home soil, including a narrow defeat to winners Brazil in the semifinals, gave promise of improved performances.
But results in friendlies remained poor and two defeats on a Scandinavian tour to Norway and Iceland earlier this month sealed Santana's fate.
Santana, who had no previous international experience, but built up his reputation in Brazilian club football, remained optimistic despite the results and was quoted on the official site www.safa.net claiming that the matches against Norway and Iceland were "good outings."